Effects of low dose intravenous sodium nitrite on arterial oxygenation and hemodynamics in experimental acute respiratory distress syndrome (ARDS)
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چکیده
Results At baseline the arterial oxygen tension (PaO2) was 539 ± 50 mmHg and 508 ± 35 mmHg in Controls and NaNO2 i.v. respectively (fraction of inspired oxygen = 1.0). PaO2 decreased to 67 ± 17 mmHg (Controls) and 57 ± 13 mmHg (NaNO2 i.v.) after ARDS induction. During the protocol, PaO2 increased to 120 ± 73 mmHg (Controls) and 103 ± 82 mmHg (NaNO2 i.v.). NOex was unchanged in both groups. Lung Wet/Dry-Ratios were 8.1 ± 0.8 (Controls) and 8.9 ± 0.7 (NaNO2 i.v.). For hemodynamic values see Table 1 (all values: mean ± SD).
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